Background: Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid used in multiple sclerosis and intractable epilepsies. Preclinical studies show CBD has numerous cardiovascular benefits, including reduced blood pressure (BP) response to stress. The aim of this study was to investigate if CBD reduces BP in humans.
Methods: Nine healthy male volunteers were given 600 mg of CBD or placebo in a randomized, placebo-controlled, double-blind, crossover study. Cardiovascular parameters were monitored using a finometer and laser Doppler.
Results: CBD reduced resting systolic BP (-6 mmHg; P < 0.05) and stroke volume (-8 ml; P < 0.05), with increased heart rate (HR) and maintained cardiac output. Subjects who had taken CBD had lower BP (-5 mmHg; P < 0.05, especially before and after stress), increased HR (+10 bpm; P < 0.01), decreased stroke volume (-13 ml; P < 0.01), and a blunted forearm skin blood flow response to isometric exercise. In response to cold stress, subjects who had taken CBD had blunted BP (-6 mmHg; P < 0.01) and increased HR (+7 bpm; P < 0.05), with lower total peripheral resistance.
Conclusions: This data shows that acute administration of CBD reduces resting BP and the BP increase to stress in humans, associated with increased HR. These hemodynamic changes should be considered for people taking CBD. Further research is required to establish whether CBD has a role in the treatment of cardiovascular disorders.
Keywords: Therapeutics; Vascular Biology.
Conflict of interest statement
Conflict of interest: GW Pharma supplied the cannabidiol (CBD) and placebo but did not fund the study.
Individual systolic and diastolic blood pressure responses to all stress tests after a single dose (600 mg) of cannabidiol (CBD) or placebo in healthy volunteers (n = 9).
Influence of cannabidiol (CBD) or its vehicle on systolic blood pressure, heart rate and body weight in conscious spontaneously (SHR) and deoxycorticosterone (DOCA) hypertensive rats and their respective normotensive controls (Wistar-Kyoto (WKY) and sham-operated (SHAM) rats).
Cardiovascular parameters were measured by the non-invasive tail-cuff method. CBD (10 mg/kg) or its vehicle were injected intraperitoneally once daily for 14 days. Data are expressed as the medians with interquartile range; $/! p< 0.05; **/$$ p < 0.01; ***/$$$/!!! p < 0.001 significantly different from the respective values obtained in normotensive groups receiving vehicle for CBD (*) or CBD ($) or recorded before the first dose of the compound (!).
The bodyweight of SHR and DOCA rats was lower than that of WKY and SHAM rats, respectively, both before the first and after the final administration of the vehicle of CBD. When animals were considered which had received CBD instead, differences were smaller or did not occur at all.
Influence of Hypertension and CBD on the Endocannabinoid System
As shown in the image below 2-AG showed the highest level among the endocannabinoids; values in the heart of normotensive WKY and SHAM rats (expressed as median (interquartile range)) amounted to 5.0 (4.7;7.5) (n = 7) and 1.3 (1.1;1.7) nmol/g tissue (n = 7), respectively. The levels of the best-known endocannabinoid AEA were relatively low, i.e., about 220 and 75 times lower than the respective values of 2-AG in WKY and SHAM rats. Although levels of PEA, LEA and OEA were higher than those of AEA, they were still lower than 2-AG levels by factors of about 15, 40 and 60 (WKY) and 5, 20 and 25 (SHAM), respectively. HEA, DEA and DGLEA showed the lowest levels, i.e., about 1–3 pmol/g tissue in all cases.
Influence of hypertension and cannabidiol (CBD) or its vehicle on endocannabinoid levels in heart isolated from spontaneously (SHR; A) and deoxycorticosterone-salt (DOCA; B) hypertensive rats and their normotensive controls (WKY (A) and SHAM (B), respectively). CBD (10 mg/kg) was injected i.p. once daily for 14 days; the respective controls received the vehicle of CBD instead; hearts were prepared 24 h after the final injection. Data are expressed as the median with interquartile range; n = 5-7; */# p < 0.05; **/## p < 0.01; *** p < 0.001 significantly different from WKY or SHAM (*) and from SHR or DOCA (#). AEA—anandamide; 2-AG—2-arachidonoylglycerol; PEA—palmitoyl ethanolamide; LEA – linolenoyl ethanolamide; OEA—oleoyl ethanolamide; SEA—stearoyl ethanolamide; DHEA—docosahexaenoyl ethanolamide; POEA—palmitoleoyl ethanolamide; HEA—homo-γ-linolenyl ethanolamide; DEA—docosatetraenoyl ethanolamide; DGLEA—dihomo-γ-linolenoyl ethanolamide; FAAH—fatty acid amide hydrolase; MAGL—monoacylglycerol lipase; m-NA—m-nitroaniline; DTNB—5,5′-dithiobis-2-dinitrobenzoic acid.
In this section, you will find answers about CBD’s effects on blood pressure. By the end, you will have a handful of information you can use to make the right decision for your health. Always consult your doctor before making any decisions about your health.
Can You Take CBD If You Have Low Blood Pressure?
As CBD has the tendency to lower blood pressure, it doesn’t always work well with blood pressure medications. One of the reasons for this is that it lowers processing for other medications, so CBD will counteract the effects of blood pressure medication. Since both substances have the power to lower blood pressure, taking it too much will lower blood pressure below normal levels. That can be very dangerous to our health.
A recent study showed that CBD lowers blood pressure. This raised a lot of concerns for people with low blood pressure taking CBD to handle their blood pressure. If you are planning to take CBD, consult your doctor so they can give you the right dosage information and the right product for you. Generally, though, it is recommended to steer clear of CBD if you have low blood pressure.
Does CBD Help with Blood Flow?
When you take topical CBD, it will successfully dilate your blood vessels. This allows oxygenated blood to flow more easily in your body. Your tissues will see an increase in blood flow. This will also help with sensitivity and promote natural lubrication in the body. Applying CBD cream on the skin will reduce mental stress and anxiety.
CBD’s Effects on Blood Pressure
You will find a wide range of products on the market dedicated to lowering blood pressure. All of them offer different features that may be unique. It is rather difficult to tell which is compatible with CBD oil. When it comes to CBD oil, it is safe and tolerable for most people. Research here is limited, so anything you hear on the internet is based on the little bit of research done on the subject. For conclusive evidence, we will have to wait for more studies to be done on CBD and its effectiveness.
As for the research and reports we have right now, it all points in the same direction. People who want to take blood pressure medication and CBD together will experience various side effects. In this article, we are going to take a deep dive into the relationship between CBD oil and blood pressure medications. By the end, you will have all the information that you need to know how to make the right decision for your health.
If you take a single dose of CBD, it will help you manage your blood pressure. Plenty of studies have been done on this subject, and all of them indicate that CBD oil will be able to reduce blood pressure by relieving stress and anxiety. CBD lowers blood pressure by widening the blood vessels. By dilating the blood vessels, the more blood flows through our tissues. A single dose of CBD will be able to lower blood pressure by reducing stress and other symptoms. It is especially helpful for people who are dealing with higher blood pressure.
Studies have shown positive signs from taking CBD to treat high blood pressure. There is plenty of research that has been done on this subject. The reports showed that CBD is beneficial to controlling blood pressure, as compared to blood pressure medications. CBD can help you deal with pain and inflammation. At the same time, though, you have drugs that can work with CBD.
There are so many drugs that are considered harmful when it comes to interacting with CBD. You should avoid them at all costs. If taken with CBD, they may result in dizziness, nausea, impaired breathing, cognitive impairment, and other critical effects. That is why you should avoid doing so at all costs. The main reason why there are so many restrictions set on these drugs is because of the substantial data needed. It is not yet available for creating proper guidelines to follow for mixing these medications with CBD.
CBD and High Blood Pressure Medication
If you want to take CBD to manage your high blood pressure medication, you need to consult your doctor for proper guidance. The medications normally used to treat high blood pressure and CBD usually don’t go well together. CBD slows down the enzymes’ processes. These enzymes are crucial to our liver for metabolizing medication. Because it slows down the enzyme process, it lessens the medication’s effects. The medication will just be sitting in your body, which may create a whole different set of side effects and symptoms.
CBD will interfere with your cytochrome P450, a pathway that other medications use for metabolism in our body. If you take blood pressure medication soon after taking CBD, you will likely feel many side effects. Some will be nausea and anxiety. That’s why it is recommended to leave a small window of time between taking each drug. You just can’t take CBD right after blood pressure medications, either; otherwise, your body would experience many other symptoms.
Some side effects may result from taking the following with CBD:
- Amlodipine Besylate
- Amlodipine besylate
CBD will reduce your blood pressure once taken, but taking a blood pressure medication will further lower your blood pressure. You can thus see how harmful mixing these can be for your health.
You can also try out the right methods of taking CBD to lower your high blood pressure. For example, many people who suffer from high blood pressure do a lot of activity to lower their blood pressure, along with taking drugs. Some of these activities include a better diet, exercise, eliminating caffeine, cycling, adding greenery to the diet, eliminating pre-processed food, and many other things to control their urges and take control of their actions. These steps will lower blood pressure and keep you healthy through the rest of your life.
Many consider mixing CBD and blood pressure medication risky. Always contact your healthcare provider before doing anything with these two drugs. Another factor in taking CBD is that it induces other enzymes in its family, which then go on to speed up the breakdown of other drugs in the body. Either way, CBD will interfere with other medications. That is not to say that there aren’t any drugs you can use along with CBD, as long as you have a doctor’s prescription for them and the amount you need to help your body run smoothly without any irregular symptoms.
CBD Oil for High Blood Pressure and Cholesterol
CBD has been shown to regulate lipid uptake and blood pressure. The anti-inflammatory and anti-anxiety prototypes of CBD provide an effective way to deal with high blood pressure and cholesterol in our body. Many full-spectrum CBD oils contain omega acid, which will help you lower your cholesterol. When it comes to research on this subject, there’s nothing conclusive yet. There is no clinical evidence supporting the claim that CBD oil that will help you reduce cholesterol. Still, some products on the market contain multiple components that may help you deal with that issue.
CBD can relieve pain, improve certain health conditions, anxiety, nausea, and many other symptoms that can come with a terminal disease. When it comes to blood pressure, CBD will interfere with other medications that you may be taking to manage your blood pressure. Some of the effects can be very dangerous. If you decide to go with CBD for blood pressure, you will see improvement in your current condition. CBD is said to do very well for individuals with this type of problem. You just have to take one drop of CBD oil to feel the effects of CBD right away.
CBD Oil Dosage to Lower Blood Pressure
If you are thinking about taking CBD to lower your blood pressure, consult your healthcare provider to give you the right advice. Many of the medications available for lowering blood pressure come with side effects like dizziness, headaches, and constipation. The change in our metabolism will interfere with medications and the supplements we take.
CBD interferes with CYP3A4, which is the core element of CYP450. Once CBD interferes with the enzyme, the metabolizing process doesn’t work like it should. This creates multiple problems in our bodies. Once metabolism slows down in our body, you will have too much medication stuck inside. It will all be waiting to be metabolized. More medication will add on unwanted side effects for your body.
At the same time, we have other substances that will up metabolism instead of slowing it down. Here, the opposite occurs since the medication will not be available in your body. In a 2017 study, a single 600mg dose of CBD was given to nine healthy male volunteers. The results show a reduction in blood pressure compared to the medication available on the market.
CBD is more tolerable and has fewer side effects. That is why many doctors prefer CBD over any other medications. But more research needs to be done; in the meantime, talk with your doctor about a proper course of action. If your body doesn’t work well with CBD, it will produce mild unpleasant symptoms.
Lastly, you need to consult your doctor before you take or make any decision regarding your health. Not all drugs work well with our systems. Some people will be able to handle a drug, while others will see a rise in symptoms. That is why you should always contact your healthcare provider before making the decision to buy anything or mix any drugs to boost their effects. This will save you plenty of rough nights filled with painful side-effects.
Does CBD Oil Lower Blood Pressure and How Long Does it Take?
Recent research has linked CBD with several benefits for the heart and circulatory system, including the ability to lower high blood pressure. One recent study treated nine healthy men with one dose of 600 mg of CBD oil and found it reduced resting blood pressure, compared to a placebo.
CBD Study and How Much Does it Reduce Blood Pressure?
CBD lowers blood pressure by dilating blood vessels, allowing more blood flow, leading to lower blood pressure. In a 2017 study, a single dose of 600 mg of CBD oil or placebo was administered to nine healthy male volunteers. The resulting data showed that acute administration of CBD reduced resting blood pressure compared to the placebo.\nThe men were then given a series of stress tests to increase heart rate. The men who were given 600 mg of CBD had lower stress-induced blood pressure spikes than the control group.\nIt’s amazing, but it’s true. A single dose of 600 mg of CBD lowered the blood pressure of men who were resting or under stress.\nThe sample size of these studies was small and further research is required to establish whether CBD has a role in the treatment of cardiovascular disorders, but the results are promising.
What Is The Effect of CBD and THC on Blood Pressure?
Cannabinoids exert different effects on blood pressure depending on the route of administration and the frequency of use. A National Health and Nutrition Examination Survey study of more than 12,000 adults found that when compared with never users, cannabis users had higher systolic, but not diastolic, blood pressure. The researchers noted that for daily cannabis users, the increase in systolic blood pressure was a modest 3 mm Hg, which may be difficult to discern in clinical practice.
How Long Does it Take for Blood Pressure and Sugar to go Down on CBD?
Vaping. Inhaling vaporized CBD oil (with the use of vaping pens or e-cigarettes) is the fastest way to experience effects. Compounds are absorbed directly from the lungs into the bloodstream. However, vaping could cause other harmful side effects such as airway irritation or damage.
- Oils and tinctures. Oils placed (via dropper) under the tongue absorb quickly into the bloodstream. Drops can also be added to foods or beverages.
- Edibles. These gummy-like candies or chocolates are good options for those who have trouble swallowing pills. Time from ingestion to effect can take a while.
- Pills and capsules. CBD pills and capsules contain a version of an oil or tincture. The time from ingestion to effect can take a while.
- Skin creams and lotions. Topical CBD creams are often applied to the skin to ease muscle or joint pain. Most topicals don’t enter the bloodstream. Instead, they affect local cannabinoid receptors in the skin.
Recent Clinical Studies of Cannabinoids in Oncology Patients.
CBD will help you deal with many of the symptoms that surface from high blood pressure. However, you should not take CBD with other blood pressure medications. By doing so, you will create more problems than you solve. Before taking any steps regarding your health, consult your healthcare provider to learn about any precautions you should take before trying out any drug.