CBD Oil

What are the Side Effects of CBD Oil?

What are the Side Effects of CBD Oil

CBD Oil Side Effects: Introduction

First, more studies researching CBD side effects after real chronic administration need to be conducted. Many so-called chronic administration studies, cited here were only a couple of weeks long. Second, many trials were conducted with a small number of individuals only. To perform a thorough general safety evaluation, more individuals have to be recruited into future clinical trials. Third, several aspects of the toxicological evaluation of a compound such as genotoxicity studies and research evaluating CBD effect on hormones are still scarce. Especially, chronic studies on CBD effect on, for example, genotoxicity and the immune system are still missing. Last, studies that evaluate whether CBD-drug interactions occur in clinical trials have to be performed.

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The CBD safety profile is already established in a plethora of ways. However, some knowledge gaps detailed above should be closed by additional clinical trials to have a completely well-tested pharmaceutical compound.

Research On CBD Side Effects: Symptoms, Dose, And Studies On Cannabis

For several years, other pharmacologically relevant constituents of the Cannabis plant, apart from Δ9-THC, have come into the focus of research and legislation. The most prominent of those is cannabidiol (CBD). In contrast to Δ9-THC, it is nonintoxicating but exerts a number of beneficial pharmacological effects. For instance, it is anxiolytic, anti-inflammatory, antiemetic, and antipsychotic. Moreover, neuroprotective properties have been shown.1,2 Consequently, it could be used at high doses for the treatment of a variety of conditions ranging in psychiatric disorders such as schizophrenia and dementia, as well as diabetes and nausea.1,2

At lower doses, it has physiological effects that promote and maintain health, including antioxidative, anti-inflammatory, and neuroprotection effects. For instance, CBD is more effective than vitamin C and E as a neuroprotective antioxidant and can ameliorate skin conditions such as acne.3,4

The comprehensive review of 132 original studies by Bergamaschi et al. describes the safety profile of CBD, mentioning several properties: catalepsy is not induced and physiological parameters are not altered (heart rate, blood pressure, and body temperature). Moreover, psychological and psychomotor functions are not adversely affected. The same holds true for gastrointestinal transit, food intake, and the absence of toxicity for nontransformed cells. Chronic use and high doses of up to 1500 mg per day have been repeatedly shown to be well tolerated by humans.1

Nonetheless, some side effects have been reported for CBD, but mainly in vitro or in animal studies. They include alterations of cell viability, reduced fertilization capacity, and inhibition of hepatic drug metabolism and drug transporters (e.g., p-glycoprotein).1 Consequently, more human studies have to be conducted to see if these effects also occur in humans. In these studies, a large enough number of subjects have to be enrolled to analyze long-term safety aspects and CBD possible interactions with other substances.

This review will build on the clinical studies mentioned by Bergamaschi et al. and will update their survey with new studies published until September 2016.

CBD oil is very beneficial to general health, but like any other medicine, it also comes with its own set of warnings. The side effects of CBD oil may not exhibit itself during the first usage, but as time goes on, they start showing. This is mainly because no two human bodies are the same, and our bodies react individually to a stimulant.


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Potential CBD Side Effects

Throughout this article, you will learn about the potential side effects that come from using CBD oil to gain the knowledge needed to make an informed choice.

CBD And Nausea

Animal studies and customer testimonials show that people who use CBD oil drops experience stomach discomfort and nausea. Despite CBD being a cure for nausea, it can also cause sensitive stomachs when not used properly. Consuming CBD oil with an empty stomach is the primary cause of nausea, so its recommended to take CBD 60 minutes after a meal.

Dryness Of The Mouth

CBD oil drops can also lead to dry mouths in some people. Studies supporting this theory is limited, but one study conducted in 2006 from a male rat observation showed that cannabinoids interact with our endocannabinoid receptors, inhibiting the CB1 and CB2 that regulate the generation of saliva. Thus, resulting in low amounts of saliva produced and an increase in dry mouth.

Dizziness

Individuals who consume high doses of CBD with CBD vape pens often will report feelings of dizziness. Since vapes pens have a high absorption rate, it can hit you hard if you inhale a lot. Nonetheless, this may be a placebo effect. Actual dizziness results from a fall in blood pressure.

Drowsiness

Different studies and customer reports show that there’s a possibility of becoming drowsy after consuming from CBD oil. Drowsiness can be a beneficial aspect of CBD oil drops based on an individual perspective. Higher dosages of CBD usually lead to drowsiness, and this is the main reason why CBD people with sleep-related issues use it.

Change In Mood Or Appetite

CBD can also profoundly affect mood and appetite in some patients. This is an indirect symptom that results from anxiety treatment, and it usually results in reduced appetite and mood swings. Nonetheless, CBD may also increase appetite, especially when combined with other compounds such as THC.

Diarrhea

Individuals with weaker stomachs may also experience diarrhea after using CBD oil. This is a rare case, especially for someone who ingested CBD oil while on a full stomach.

Lack Of Effectiveness

More effectiveness means fewer side effects, but there are some patients who don’t feel the effects of CBD at all. This may be as a result of inconsistently using CBD oil or using minimal dosages of CBD oil.

Headaches And Migraines

There’s a chance that CBD oil can lead to headaches. This is because CBD is recommended as an alternative for patients with migraines and headaches. But some individuals who experience slight headaches after using hemp CBD oil may blame it on the brand of oil, the source of the and overall bad ingredients.

Liver Problems

Recent reports identify liver problems with CBD oil usage. According to the FDA, liver issues were discovered through multiple studies. The leading cause of liver issues is because of inhibition or blockage of liver-helping medication, which results in poor functioning of the liver. Therefore, individuals with any liver issues should avoid using CBD oil.

CBD Oil Side Effects On Kidneys

There are some opposite opinions on this one. According to one study, cannabis is beneficial for patients with advanced chronic kidney disease (CKD). It helps them regulate the pain and exhibits no side issues.

In another research, though, it was found that cannabis has an adverse effect, especially if it’s consumed via smoking. Patients were advised against medical marijuana, and CBD oil possibly could have the same effect.

What are the side effects of CBD for healthy people? Apparently, none. Those who did not suffer from kidney disease did not show any reduction in kidney functions while using cannabis.

Affect Medications That Have Grapefruit Warnings

New information shows that CBD can affect the same medications that have restrictions on grapefruit due to its interaction with the same enzymes of the body as grapefruit. Reports from Forbes show that both grapefruit and CBD comprise of compounds that bind and neutralize enzymes in the gut (CYP450 enzymes), thus helping to remove the compound from the body altogether.

Since the enzymes have limits, the compound quickly enters the liver and flow at higher levels while remaining in the body. This can cause small doses to be extremely high. CBD can even harm the body if it binds with enzymes in the liver and gut.

Lower Blood Pressure

In addition to reacting to grapefruit medications, CBD may also act as a blood thinner, meaning it possibly lowers blood pressure. This can be a risk to individuals who depend on blood-thinning medications. Also, individuals undergoing surgery should avoid using CBD oil or products for a week to prevent any potential effects.

Increased Effectiveness

CBD can become more effective when it’s used for a long period of time. Therefore, over a long period, individuals may not need to take the same MG of CBD to gain maximum effects. This also means that after using CBD oil for a few months, users should lower their doses to see if the results are the same.

Worsened Symptoms From Parkinson’s Disease

Recent studies suggest that CBD oil can be beneficial for Parkinson’s patients mainly when used at lower dosages. Preliminary reports from scientific studies show that high doses of CBD oil may make the symptoms of Parkinson’s Disease to worsen. It’s recommended consulting your physician before trying CBD oil for Parkinson’s Disease.

Vomiting

Vomiting is a rare side effect of CBD oil. A study from 2011 on rats discovered that cannabinoids reduce vomiting because of how it affects the CB1 receptors. Keep in mind that CBD reduces nausea by interacting with CB 1 receptors as well. However, in rare cases where vomiting occurs, patients should evaluate their entire diet. Vomiting can result from a lot of factors, including nausea. So, using CBD to reduce nausea may have caused the vomiting to begin with.

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Which bioMD+ product is BEST for YOU?

Citrus CBD Oil (Full Spectrum)

256 Reviews From: $65.00$32.50 or from From: $65.00$29.25 every 28 days

Full Spectrum CBD Oil (Natural)

277 Reviews From: $65.00$32.50 or from From: $65.00$29.25 every 28 days

Vanilla CBD Oil (Full Spectrum)

74 Reviews From: $65.00$32.50 or from From: $65.00$29.25 every 28 days

Citrus CBG:CBD Oil (Full Spectrum)

64 Reviews $230.00$115.00 or $230.00$103.50 every 28 days

Citrus CBD Oil (Full Spectrum)

256 Reviews From: $65.00$32.50 or from From: $65.00$29.25 every 28 days

Full Spectrum CBD Oil (Natural)

277 Reviews From: $65.00$32.50 or from From: $65.00$29.25 every 28 days

Cold Therapy Menthol & CBD – Pain Relief Cream

42 Reviews $65.00$32.50 or $65.00$29.25 every 28 days

Mint CBD Oil (Full Spectrum)

147 Reviews From: $65.00$32.50 or from From: $65.00$29.25 every 28 days

Full Spectrum CBD Oil (Natural)

277 Reviews From: $65.00$32.50 or from From: $65.00$29.25 every 28 days

Mint CBD Oil (Full Spectrum)

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Bottom line

The potential side effects of CBD may not be as severe as the effects which result from most medical treatments or drugs, like opiates. This is why CBD can be a powerful treatment for some medical conditions. CBD can help different cases, including extreme conditions such as cancer, tumors, and seizure. Present studies show that CBD can help with different types of symptoms or issues. Also, the current benefits of CBD oil outweigh the possible side effects of CBD oil entirely.

Sources

Iffland, K., & Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and cannabinoid research, 2(1), 139–154. https://doi.org/10.1089/can.2016.0034

Parker, L. A., Rock, E. M., & Limebeer, C. L. (2011). Regulation of nausea and vomiting by cannabinoids. British journal of pharmacology, 163(7), 1411–1422. https:/doi.org/10.1111/j.1476-5381.2010.01176.x

Azriel Adelberg
About Azriel Adelberg

MSc Chemistry, University of California, Berkeley An Israeli born organic chemist and PROUD University of California, Berkeley graduate.

4 thoughts on “What are the Side Effects of CBD Oil?
  1. Avatar Mee Avalos says:

    CBD broad spectrum gave me a ton of energy.

  2. Avatar Marcia Seto says:

    CBD is safe, I have no problems 🙂

  3. I’m interested in how it would interact with a hard core pain medication.

  4. Avatar Marnie Sloan says:

    I have Parkinson’s. I take 1500 strength.internally 2 drops under my younger.for anxiety,pain,tremors,headache. I pu t2/3 drops on inside of my wrist rub together and on top up inside and top of hands.for headache I put dots across my forehead

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